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Symbol Name ID |
Nos3
nitric oxide synthase 3, endothelial cell MGI:97362 |
| Darker colors indicate more annotations |
| Human Phenotypes | Sinusitis |
Chronic sinusitis |
Pulmonary arterial hypertension |
Recurrent pneumonia |
Asthma |
Recurrent respiratory infections |
Recurrent bronchopulmonary infections |
Recurrent lower respiratory tract infections |
Hypoxemia |
Bronchoconstriction |
Pneumothorax |
Hemoptysis |
Bronchiectasis |
Decreased forced expiratory flow 25-75% |
Reduced forced expiratory volume in one second |
Reduced forced vital capacity |
Airway hyperresponsiveness |
Airway obstruction |
Chronic lung disease |
Hyperpolarized transepithelial nasal potential difference |
| Disease(s) Associated with NOS3 | ||||||||||||||||||||
| asthma | ||||||||||||||||||||
| cystic fibrosis | ||||||||||||||||||||
| sickle cell anemia |
| Mouse Phenotypes | abnormal lung vasculature morphology |
pulmonary vascular congestion |
lung hemorrhage |
pulmonary alveolar edema |
abnormal lung morphology |
abnormal type II pneumocyte morphology |
absent alveolar lamellar bodies |
abnormal pulmonary alveolus morphology |
thick pulmonary interalveolar septum |
respiratory distress |
abnormal surfactant secretion |
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| Availability | Mouse Genotype | |||||||||||
| Nos3tm1Plh/Nos3tm1Plh | ||||||||||||
| Nos3tm1Unc/Nos3tm1Unc | ||||||||||||
| Nos3tm1Plh/Nos3+ | ||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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